Search results for "choroidal melanoma"
showing 5 items of 5 documents
DEXAMETHASONE INTRAVITREAL IMPLANT VS RANIBIZUMAB IN THE TREATMENT OF MACULAR EDEMA SECONDARY TO BRACHYTHERAPY FOR CHOROIDAL MELANOMA
2017
PURPOSE To evaluate the efficacy of an intravitreal dexamethasone (Dex) implant 0.7 mg compared with intravitreal ranibizumab (Ra) for the treatment of radiation maculopathy with macular edema secondary to plaque brachytherapy in choroidal melanoma. METHODS Eight patients were treated with intravitreal Ra, and eight patients received the Dex intravitreal implant. Visual acuity and foveal thickness were evaluated using spectral domain optical coherence tomography. RESULTS The mean calculated irradiation to the fovea and mean times from brachytherapy to maculopathy development did not differ significantly between groups. In the Ra group, a mean 7.8 ± 3.9 injections were given and the mean fol…
Mosaic activating mutations in GNA11 and GNAQ are associated with phakomatosis pigmentovascularis and extensive dermal melanocytosis
2016
Common birthmarks can be an indicator of underlying genetic disease but are often overlooked. Mongolian blue spots (dermal melanocytosis) are usually localized and transient, but they can be extensive, permanent, and associated with extracutaneous abnormalities. Co-occurrence with vascular birthmarks defines a subtype of phakomatosis pigmentovascularis, a group of syndromes associated with neurovascular, ophthalmological, overgrowth, and malignant complications. Here, we discover that extensive dermal melanocytosis and phakomatosis pigmentovascularis are associated with activating mutations in GNA11 and GNAQ, genes that encode Gα subunits of heterotrimeric G proteins. The mutations were det…
Tumorregression maligner Aderhautmelanome nach Transpupillarer Thermotherapie (TTT) versus Ruthenium-Brachytherapie und Sandwichtherapie – eine vergl…
2010
PURPOSE: The aim of this study was to evaluate tumour regression in a large series of choroidal melanomas, which were treated with three different eye-sparing treatment modalities. PATIENTS AND METHODS: Retrospective review of the treatment results in all eyes with malignant choroidal melanoma, which were treated in the University Eye Clinic of Mainz consecutively in the time span 1.1992 to 12.2000 with transpupillary thermotherapy (TTT, standard protocol Oosterhuis JA 1995), ruthenium brachytherapy (RB, tumor apex dose 150 Gy) or sandwich therapy (ST). One-step ST was defined as TTT followed by RB with 100 Gy tumor apex dose within 48 hours. The treatment of residual prominences with TTT s…
Der infrarote Diodenlaser (810 nm) zur transpupillaren Thermotherapie des malignen Aderhautmelanoms
1999
Zusammenfasssung Ziel: Die transpupillare Thermotherapie (TIT) ist eine neue Therapieoption fur das maligne Aderhautmelanom, die uberwiegend adiuvant zur Brachytherapie eingesetzt wird. Wir demonstrieren den Therapieverlauf nach TTT zur alleinigen Primartherapie eines malignen Aderhautmelanoms. Patient und Methode: Durchfuhrung der TTT und postoperativer Behandlungsverlauf eines Patienten mit subfovealem 1,7 mm prominentem malignem Aderhautmelanom werden exemplarisch in einem Video dargestellt. Die Behandlung erfolgte mit einem modifizierten Diodenlaser (810 nm), wobei unter spaltlampen-mikroskopischer Kontrolle eine grau-weiβ Farbung der Tumoroberflache angestrebt wurde (konstante Fleckgro…
Primary transpupillary thermotherapy (TTT) for malignant choroidal melanoma
2002
. Purpose: To evaluate the efficacy of transpupillary thermotherapy (TTT) as the only method of treatment for small choroidal melanoma. Patients and Methods: In a prospective non-randomized analysis, 20 patients with primary choroidal melanoma (posterior to the equator with base ≤ 2 and thickness ≤ 4.5 mm) were treated with TTT as the only method of treatment (diode laser at 810 nm, beam diameter 3 mm, power setting 0.3–0.9 W, exposure time 20–37 min). During follow-up of at least 6 months, clinical aspects, ultrasonographic tumour thickness, fluorescein and indocyanine green angiographic patterns, visual acuity and ocular side-effects were recorded. Results: In 17 eyes the tumour regres…